Brain aging research at the close of the 20th century: from bench to bedside
نویسندگان
چکیده
Remarkable and continued growth in the field of brain aging research has been fueled by a confluence of factors. Developments in molecular biology, imaging, and genetics coupled with the imperative caused by the aging of the population has created fertile ground for improved understanding of the interaction between brain function and behavior. Aging changes in neurochemical systems may account for the spectrum of cognitive and behavioral states of successfully aged pen sons, but may also contribute to enhanced vulnerability to depressive or dementing illness. In particular, the refinement of in vivo imaging approaches to investigating the structure and function of the aging brain has provided the opportunity to strengthen our knowledge of the biological substrate of the aging brain and neuropsychiatrie disorders, and translate these into therapeutics.
منابع مشابه
Promising role for Gc-MAF in cancer immunotherapy: from bench to bedside
Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics...
متن کاملTranslational Antidote Research: A Bedside to Bench Tale
Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...
متن کاملA Need to Address Different Dimensions of Aging Challenges of Iranian Elderly for Publishing in Elderly Health Journal
According to a report by world health organization (WHO) in 2018, the population of the elderly over 60 years will double from 2015 to 2050, and will increase between12% to 22%. Also, in 2050, 80 % of the elderly will be from low and middle-income countries. Though population changes toward aging has begun from developed countries such as Japan, but in the middle of the 20th century, the elderl...
متن کاملThe Aesthetics of the Machine in the 20th Century Art based on Don Ihde’s Ideas
The increasing growth of technology in the twentieth century has brought about profound developments in the relations between man and the world. These developments, which included large industries and automatic and semi-automatic machines, necessitated the question of technology not only by intellectuals, but also by artists. Thus, different approaches to technology were formed, all of which we...
متن کاملALTERATIONS OF ADP-RIBOSYLATION AND DNA-BREAKS IN AGING BRAIN CELLS
Neuronal and astroglial cells were prepared from whole brain of three month and 30-month- old rats for study of alterations in the nuclear poly ADP-ribosylation and DNA breaks with age. The relative purity of the cell preparations was confirmed by the determination of the neurofilament (low molecular weight) and glutamine synthetase content of the cells using ELISA. An increase (75%) in th...
متن کامل